Compromised mitochondrial health

Importance of mitochondrial health quality control
“Mitochondria, as the “powerhouse” of eukaryotic cells, play the key role in central signalling pathways decisive for the cell fate (proliferation, differentiation, growth and death) as well as systemic events and effects including stress response towards environmental changes, redox balance, the innate and acquired immunity as well as severity of the acute and chronic disorders. Up to now no any health condition has been reported which mitochondrial functionality would be irrelevant for. Moreover, accumulated research data demonstrate that aside from the energetic aspects which are decisive for the health and death at the sub/cellular, tissue, organ and organismal levels, injured mitochondria do release specific damage-associated molecular patterns.
To this end, cell-free mitochondrial (mtDNA) fragments are recognised as the “mitochondrial burnout” signals triggering systemic effects such as non-infectious (sterile) inflammation, which are further involved in pathomechanisms of downstream diseases. Well-known mitochondrial burnout-associated pathologies include chronic fatigue, accelerated ageing, auto/immune disorders, hormonal dysregulation and infertility, eye pathologies, metabolic and mood disorders, severe respiratory diseases, impaired healing, neurodegenerative and cancerous alterations.
There is an evident reciprocity between mitochondrial and organismal health status: compromised mitochondrial health is reflected in systemic damage as well as organismal health-to-disease transition is reflected in mitochondrial dysfunction. Contextually, routine non-invasive mitochondrial health quality control test is a powerful tool for the holistic predictive diagnostic approach in PPPM-framework highly recommended at the level of primary and secondary care for

• the whole-body health quality check-up

• pre-pregnancy check-up

• health-to-disease transition check-up

• accompanying diagnostics in sport medicine and supervised physical activities

• accompanying diagnostics in physiotherapeutic and well-being services

• therapy efficacy monitoring for personalised treatments (e. g. chronic fatigue; burnout syndrome and sleep disorders; eye, skin, kidney, liver and respiratory diseases, endocrine and cardio-vascular impairments, musculoskeletal- and neuro-degenerative disorders, depression etc.).”

(Quotation from the book chapter: Golubnitschaja O., “What is the routine mitochondrial health check-up good for? A holistic approach in the framework of 3P medicine”, in the book “PREDICTIVE, PREVENTIVE AND PERSONALISED MEDICINE: From Bench to Bedside”, hardcover: ISBN 978-3-031-34883-9, eBook: ISBN 978-3-031-34884-6, in the book series “Advances in Predictive, Preventive and Personalised Medicine” – see here: springer.com/series/10051)

Tear fluid analysis as a non-invasive indicator of risks
The examination of tear fluid is advantaged against blood analysis, due to much more stable molecular patterns and non-invasive collection of basal tears.
Patterns identified during the laboratory analysis of tear fluid are instrumental for individualised health risk assessment, such as detection of indicators pointing to a potential predisposition to eye disorders, or increased risks of ischemic stroke and neurodegenerative processes, amongst others.
A long-term tracking of the development is possible by repeating the procedure regularly (e. g. annually).